Vitamin D and Vitamin D Receptor in Scleroderma Subtypes
نویسندگان
چکیده
منابع مشابه
Vitamin D, vitamin D receptor and tissue barriers
Tissue barriers are critical in the pathogenesis of human diseases, such as atopic dermatitis, inflammatory bowel diseases, and various cancers. Preserving or restoring barrier functions of the epithelia cells is a therapeutic strategy to prevent and treat the illness. Mounting evidence indicates that vitamin D and the vitamin D receptor (VDR) play key roles in the pathogenesis of human disease...
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In chronic kidney disease (CKD), high circulating levels of parathyroid hormone (PTH) cause osteitis fibrosa, bone loss, and cardiovascular complications that increase morbidity and mortality. Impaired production of 1,25-dihydroxyvitamin D (calcitriol), the hormonal form of vitamin D, is a major contributor to the generation and maintenance of parathyroid hyperplasia and increased synthesis and...
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Vitamin D comprises a group of fat-soluble pro-hormones, obtained from sun exposure, food, and supplements, and it must undergo two hydroxylation reactions to be activated in the body. Several studies have shown the role of vitamin D in mineral metabolism regulation, especially calcium, phosphorus, and bone metabolism. Some factors such as inadequate vitamin intake and liver or kidney disorders...
متن کاملfgf-23, klotho and vitamin d levels in scleroderma
background: scleroderma is a chronic connective tissue disease of unknown etiology. vitamin d and parathyroid hormone (pth) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. klotho, the co-receptor of the fibroblast growth factor 23 (fgf-23), can interfere with calcium and phosphate metabolism. the purpose of this study was to ...
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ژورنال
عنوان ژورنال: Journal of Advances in Medicine and Medical Research
سال: 2020
ISSN: 2456-8899
DOI: 10.9734/jammr/2020/v32i2030677